Clotting and bleeding conditions

 

Hereditary thrombophilias

  1. Screening for thrombophilia should be considered in individuals with:
  2. DVT <50 yrs
  3. Spontaneous thrombosis in absence of recognised risk factors
  4. Recurrent thrombosis
  5. Family history of thrombosis
  6. Thrombosis in unusual sites eg CNS, abdominal veins, upper limb
  7. Stillbirth or fetal death in utero
  8. A thrombophilia screen (factor V Leiden, prothrombin variants, antithrombin III deficiency, protein C deficiency, protein S deficiency and activated protein C resistance) is available on the MBS only if the patient has:
  9. A personal history of proven venous thromboembolism or pulmonary embolism, or
  10. A 1° relative who has a proven defect of any of the above
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Haemophilias

  1. Haemophilia A is caused by low or absent factor VIII and haemophilia B is caused by low or absent
    factor IX
  2. X-linked recessive pattern of inheritance
  3. Males are affected
  4. 10% of female carriers can have mild bleeding symptoms.
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